MODULE 1:
PHARMACODYNAMICS AND PHARMACOKINETICS
Learning Objectives
- Distinguish between pharmacodynamics and pharmacokinetics
- Describe drug movement throughout the body
- Identify barriers and obstacles for drugs in the body
- Explain concepts of kinetics and their clinical importance
- Identify variables affecting kinetics and their relation to drug dosing
- Explain toxicities and their relation to on-target or off-target responses
Table of Contents
- Drug-Receptor Model
- Protein Structure
- Drug Binding
- Active Site
- Drug Design
- Receptor Types
- Cellular Regulation
- Self Check Questions: Drug-Receptor Model
- Pharmacodynamics
- Pharmacokinetics
- Kinetic Overview
- Absorption
- Distribution
- Metabolism
- Excretion
- Half-Life (T 1/2)
- Therapeutic Dosing and Frequency
- Pharmacogenomics
- Drug-Drug Interactions
- Drug Toxicity
- Drug Toxicity Overview
- Mechanisms
- Metabolites
- Pathology of Drug Toxicity
- Carcinogenisis/Teratogenisis
- Module 1 Case Studies
