Dose Response Relationships

Let's look at what dose-relationship curves look like on a linear and semi-logarithmic scale:


Let's first look at G-graded dose response curves:


Now we'll look at Quantal dose response curves and critical points used in determining dosing and safety:


Let's revisit our drug receptor complex equation and the relationships it represents:

drug + receptor drug-receptor cplx.

k1 = association constant

k2 = dissociation constant

k1 / k2 = AFFINITY


Types of Agonists/Antagonists

This diagram highlights the possible site for antagonist binding:



This diagram shows different types of antagonist binding and their effect on the agonist binding:



Let's take a look at a graphic representation of several types of binding and the outcomes of the overall therapeutic effect: 



Let's now look at a comparative diagram of full versus partial agonists: 



In this diagram we will look at the effect spare receptors can have on the effectiveness of an antagonist.


Self Check Questions: Pharmacodynamics

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Pharmacodynamics are very important to determine? Check all that apply

[mark all correct answers]

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Graded dose response relationship curves show the effect of various doses on a population and look for a specific response, such as sleep or not asleep.

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If drug A has an EC50 of 10mg and drug B has an EC50 of 100mg

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In regards to this equation K1/K2 represents?


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Drugs can have a high affinity and not have efficacy.

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Competitive antagonists:



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